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Warrior or Worrier? The truth about COMT

Catechol-O-methyltransferase (COMT) is one of several enzymes that degrade catecholamines such as dopamine, epinephrine, and norepinephrine. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. COMT is mostly found in the peripheral nervous system, and less significantly found in the Central Nervous System, and found in the highest concentration in the liver.

There are 2 types of COMT expression, the warrior and the worrier.


Generally have a higher IQ

do better on tests

better toxin elimination

higher estrogen elimination

higher incidence of ADHD

Higher pain tolerance

Normal magnesium levels

Normalized B12 and folate levels

Even tempered


Slower estrogen elimination and estrogen dominance Lower